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Five effects of folic acid [2024] Contraindications cannot be ignored!

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Folic acid, English is Folic acid or Floate The noun that often appear with pregnancy seems to be exclusive vitamins for pregnant women, but they do not know that all people need the ingredient of folic acid.Folic acid has an important role in genetic factors such as DNA and RNA, which is why it has become an important vitamin during pregnancy.

Folic acid also plays an important role in the process of making red blood cells in the human body, which is even more important for everyone.So what exactly is folic acid?Do I need to add extra folic acid?Does folic acid have side effects?

Directory of this article

What is folic acid?

Folic acid is a collective name for a set of compounds with similar nutritional characteristics.Folic Acid and Floate are two forms of vitamin B9.

  • Floate: It is the natural existence of vitamin B9.It is named in Latin “Folium”, which means leaves, because many leafy vegetables contain natural folic acid, which is one of the best food sources of folic acid.
  • Folic acid: It is an artificial synthetic form of vitamin B9, also known as pteroylMonoglutamic Acid, which is a dietary supplement added to the processing food for supplementing the folic acid content required by the human body[1]Essence

Folic acid helps the human body to create genetic materials such as DNA and RNA in the early stage of development.The genetic material is transmitted to all parts of the body through the nerve tube.The complete and healthy genetic material is a necessary part of the normal development of the fetus.Therefore, folic acid is so important before and during pregnancy.[2]Essence

Folic acid is also involved in making red blood cells and white blood cells from the bone marrow, and transforming carbohydrates into abilities.Therefore, for people at any time after birth, folic acid is a necessary nutritional element for nutritional elements.[3] Essence

What are the effects of folic acid?

Folic acid plays a very important role in the human body, such as promoting embryo development, making red blood cells, reducing stroke risks, and so on.The effect of folic acid is as follows:

1.Promote the healthy development of embryo

When pregnancy cells begin to divide, genetic factors will determine the development of embryos.Especially in the first few weeks of pregnancy, the nerve tube is open, and all genetic information will be transmitted to all parts of the body.

Folic acid plays an important role in genetic factors, and whether the correctness of genetic factors will determine whether the fetal organs, brain function, external bone skin can develop normally[4] [5]Essence

Therefore, for pregnant women, it is important to supplement folic acid.

2.Create red blood cells

Red blood cells exist in human blood, and its main function is to transport oxygen and nutrients to all parts of the body throughout the body.

Folic acid plays an important role in the process of bone marrow manufacturing red blood cells, and enough folic acid content will help the human body maintain the ideal red blood cell level[2]Essence

3.Prevention of autism spectrum dysfunction

The autism spectrum dysfunction English is Autism Spectrum Disorder, referred to as ASD.

Autism and genetic factors have a certain relationship, which may be related to the role of folic acid in DNA methylation.

Research observation has proved that supplementing folic acid during pregnancy may reduce the risk of ASD, or reduce the risk probability of suffering from ASD in the later period due to the contact with certain drugs or toxic chemicals before giving birth.[6]Essence

4.Prevent or slow cancer development

A variety of pathological studies have shown that the intake of folic acid and the probability of the disease risk of cancer is negatively related, including colorectal cancer, lung cancer, pancreatic cancer, esophageal cancer, gastric cancer, cervical cancer, ovarian cancer, breast cancer, Bladder cancer, etc.

Although the clear anti-cancer mechanism has not yet been confirmed, scientists believe that it may be due to the role of folic acid in one carbon metabolism and the subsequent impact on DNA replication and cell division to prevent the occurrence of cancer.

There are also research evidence that folic acid also has a certain effect in the process of slowing the development of cancer.The appropriate amount of folic acid intake may rise early in cancer.[7] [8]Essence

5.Reduce stroke risk

An experiment was performed in areas where human folic acid is generally low.It divides adults with hypertension but no history of stroke or myocardial infarction.Pressure, the other group only takes the Irinubi antihypertensive drug.

After many years of tracking health data, it is found that the crowd of folic acid groups is reduced by 21%compared with only taking the antihypertensive drug group, and the lower the content of folic acid in the initial body of the subject, the more obvious the comparison effect.

But this contrast is not obvious among people with sufficient initial folic acid content in the body[9]Essence

What are the symptoms of folic acid deficiency?

Folic acid is not harmful to the human body, especially for pregnant women, which will adversely affect children in the fetus.

Folic acid deficiency has the following symptoms:

A.anemia

Because folic acid plays a certain role in the process of producing red blood cells in the human body, the lack of folic acid will reduce the content of red blood cells in the human body, thereby reducing the circulating oxygen in the body, which will cause discomfort such as fatigue, weakness, and pale complexion.It is folic acid deficiency anemia[2]Essence

B.Fetal development abnormal

Insufficient folic acid contained in pregnant women may affect children in the fetus.Its risk of NEURAL Tube Defects (NTDS) babies increased significantly.

NTDS is a severe birth defect in the brain and spinal cord, which can lead to spinal malformations, such as spinal bales, skull and brain malformations, such as no brain deformities[4]Essence

Since the United States began to force folic acid in 1998, the birth rate of NTDS babies has decreased by 28%[10]Essence

The deficiencies of folic acid on genetic diseases are another manifestation of congenital heart defects.

Studies on the growth tracking of many baby babies in California showed that the probability of supplementing enough folic acid and other vitamin mothers during pregnancy is much smaller.Folic acid cells[11] [12]Essence

In addition, the lack of folic acid in pregnant women is also related to the low weight of the baby’s birth, premature birth and the slow fetal growth[13]Essence

C.Depression

There are many causes of depression.Some studies have shown that in women’s groups, depression and folic acid lack of lack of relationship have a certain relationship.

In a study of a 2,948 -year-old population of 2,948 years, the concentration of folic acid in patients with severe depression was significantly lower than those who had never suffered from depression.

Another comparison of adults who are 2,791 years old and above found that people with higher folic acid concentration in their body have a low prevalence of depression, and this association is mainly reflected in women.No clear correlation[14] [15]Essence

What are the foods for folic acid?

American Dietary Guidepropose:

Natural folic acid exists mainly:

  • Various leafy vegetables, fruits;
  • Foods rich in protein such as lean meat, poultry, eggs and dairy products
  • Seafood products;
  • Beans such as peas, lentils, etc., as well as soy products;
  • Nuts and seeds, such as almonds, etc.;

Since its 1998, the United States forced to strengthen the intake of folic acid, so processing products such as bread, oatmeal, and pasta will add a certain amount of folic acid [16] Essence

Folic acid prepare for pregnancy?

The importance of folic acid during pregnancy is that in the early stages of embryo, folic acid can produce sufficient genetic factors such as DNA and RNA.Successively genetic factors can be conducted to all cells by neural tube to make it normal and develop normally.

The nerve tube will be closed a few weeks after the fetus starts to develop, so it is particularly important to have enough folic acid in the mother’s body before the pregnancy cells begin to divide.This is the importance of folic acid pregnancy.

When a female plan is pregnant, supplementing folic acid should be the first important task to start[17]Essence

When is folic acid eaten?

For ordinary people, folic acid can be obtained through daily diet[3]Essence

For those who have a lack of folic acid, they can supplement folic acid that can be supplemented for a certain time under the guidance of a doctor.

For pregnancy or pregnant women:

  • Preparation of pregnant women should start supplementing folic acid for more than 3 months before conception to ensure that there is enough folic acid in the body to help the fetus healthy.
  • Women pregnant women should guarantee sufficient folic acid supplement in the early stages of pregnancy, and can adjust the intake according to the doctor in the later stages of pregnancy.[17]Essence

What is the amount of folic acid?

according to National Dietary Supplement Guidance The daily daily intake recommended by people recommended by people in different ages:

  • 0 ~ 6 months: 65 micrograms/day
  • 7 ~ 12 months: 80 micrograms/day
  • 1 ~ 3 years old: 150 micrograms/day
  • 4 ~ 8 years old: 200 micrograms/day
  • 9 ~ 13 years old: 300 micrograms/day
  • 14 years old: 400 micrograms/day
  • Pregnant woman during pregnancy: 600 micrograms/day
  • Pregnant woman breastfeeding period: 500 micrograms/day

The upper limit of folic acid in different ages is[3]The

  • 6 months: cannot be established
  • 7 to 12 months: cannot be established
  • 1 to 3 years old: 300 micrograms
  • 4 to 8 years old: 400 micrograms
  • 9 to 13 years old: 600 micrograms
  • 14 to 18 years old: 800 micrograms
  • Over 19 years old: 1,000 micrograms

The upper limit of the intake is because folic acid is a member of the vitamin B family.Excessive supplementation of folic acid will cause the lack of other vitamin B ethnic elements.

In addition, excessive intake of folic acid may cause abdominal spasm, diarrhea, rash, sleep disorders, irritability, blurred consciousness, nausea, stomach discomfort, behavior changes, skin reactions, epilepsy, flatulence, excitement and other adverse reactions[18]Essence

Do I need to use folic acid every day?

In the United States, because folic acid is stored in a large amount of natural and processing foods, there is no additional daily folic acid when the diet is balanced.

For the treatment of folic acid deficiency anemia, it is recommended that the common dose of people over 1 year old is 5 micrograms per day.After 4 months of continuous taking, decide whether to continue to take it according to the blood testing index[19]Essence

For women during pregnancy and pregnancy, it is recommended to take 600 micrograms of folic acid daily to ensure sufficient reserves in the body.After entering the breastfeeding period, adjust to 500 micrograms per day[3]Essence

What are the side effects of folic acid?

If you take folic acid overdose, abdominal spasm, diarrhea, rash, sleep disorders, irritability, blurred consciousness, nausea, stomach discomfort and other adverse reactions[18]Essence

There are also studies that high-dose folic acid intake may accelerate the development of cancer[8]Essence

In addition, folic acid will also interact with some drugs to affect the effect:

  • It is a folic acid antagonist for the treatment of cancer and autoimmune diseases with methotrexate, methotrexate-METHOTREXATE, which is used to treat cancer and autoimmune diseases.Essence
  • Antiepileptic drugs, such as Phenytoin, Kamasiping-Carbamazepine, and propyate-Valproic Acid.These drugs will reduce the level of folic acid in the body.In reverse, foam acid supplements may reduce the medicinal efficacy of these drugs.Therefore, patients taking antiepileptic drugs should consult their healthcare providers before taking folic acid supplements.
  • Willow-nitroglyzine-Sulfasalazine, this ingredient is mainly used to treat ulcerative colitis.It will inhibit the absorption of folic acid in the intestine and cause folic acid deficiency.Patients taking pyrium pyridine should be asked about their healthcare providers to increase dietary folic acid intake[twenty two]Essence

Can folic acid and vitamin B12 be used at the same time?

Vitamin B12, also known as cgieomine-Cyanocobalamin, is one of the members of vitamin B, like folic acid, and naturally exists in animal food.

Vitamin B12 is also a necessary ingredient for forming red blood cells and DNA.It is an important participant in the function and development of the brain and nerve cells, so it can also be added to the food or dietary supplementary agent[20]Essence

In the current research, no obvious interaction between folic acid and vitamin B12 is found, but this does not necessarily mean that there is no mutual impact at the same time.It is always recommended to consult medical care providers[twenty one]Essence

Recommended folic acid health products

@Amazon

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Nature Made’s nutritional components can provide a series of support for babies and mothers.Each piece contains 17 other prenatal vitamins and minerals including folic acid and iron, iodine, vitamin D, vitamin C, and calcium.Vitamins such as folic acid can help support the production of cell energy, which can reduce the risk of mothers to suffer from neurotic tube defects; the common role of calcium and vitamin D, to build a strong bone for babies and mothers; iron can increase whole body cell transportationThe ability to oxygen to create a healthy growth space for the baby.

@Amazon

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Nature Made folic acid tablets, which offer 400 micrograms of high-quality folic acid each, meets the official standard content of dietary supplements formulated by US Pharmacopoeia USP.It can effectively support the normal development of the fetal neurological development system during pregnancy and the healthy development of the healthy development of the body.Essence

@Amazon

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Nature ’s Bounty folic acid tablets are provided with 800 microne-grams of folic acid content.It can effectively support heart health, cell health growth, optimize body energy metabolism, and equally important for women during pregnancy, which can reduce the occurrence of adverse defects in the growth and development of the fetus.

@Amazon

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Nutricost folic acid capsules only use the best ingredients to ensure the highest quality, and each piece provides high concentration of high-concentration folic acid with up to 1,000mcg.The provided supplements have been tested by a third-party and are manufactured in the FDA registered facilities that meet the GMP.Proposal using non-rotor raw materials and without gluten.

@Amazon

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Best Natures folic acid tablets are made of high-quality folic acid.They are tested by third-party independent laboratory.The ingredients are safe and effective, and do not contain artificial pigment, spice or sweetener, no preservatives, sugar-free, starch without corn, no corn-free corn containing cornIt does not contain soybeans, eggs, lactose, gluten, no wheat, no yeast, non-containing fish and other non-necessary ingredients, only to provide the purest quality.All products are produced and distributed on devices stipulated in GMP.

@Amazon

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Frunutta folic acid tablets are designed as a compact volume, which are soluble in the mouth for a few seconds, spread directly into the blood, and provide faster and more complete absorption.There is no need to swallow, no need to drink water, make the dietary supplement more comfortable and convenient.All products are produced in California’s FDA registration and NSF-certified factories in accordance with strict GMP standards.Each batch of raw materials and finished products have undergone the purity and effectiveness test of the independent ISO 17025 certification laboratory.It does not contain additives such as preservatives, genetically modified biology, gluten, sugar, and color.

@Amazon

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21st Century folic acid tablets, as your ideal vitamin supplement, each tablet contains 400mcg folic acid ingredients to meet the US dietary guidance standards, tablets are easy to swallow, and regular use is beneficial to heart health.

@Amazon

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GNC folic acid tablets each contains 1,000mcg folic acid, which can provide necessary growth elements during the dirty development stage of the fetus, reducing the probability of generating physiological defects.In the past century, GNC has been committed to achieving the highest standards of quality, safety and efficacy.At the same time, the latest progress of nutritional science can make you live better.

references

[1] Atli Arnarson BSC, Folic Acid vs.FOLATE -What ’s the Difference? August 19, 2019.

[2] Kathy W.Warwick, R.D., Adam Felman.What to know about folic acid.March 11, 2020.

[3] Folate.NATIONAL Institutes of Health.

[4] Institute of Medicine.DietaRY Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, FOLATE, VITAMIN B12, Pantothenic Acid, Biotin, and Choline.Washington, dc: National Academy Press; 1998.

[5] Shaw GM, O’Malley CD, WASSERMAN CR, et al.Maternal PericOnceptional Use of Multivitamins and Reduced Risk for Conotruncal Heart Defects and Limb DEFICIENCIES AMONG Office.AM J Med Genet 1995; 59: 536-45.

[6] DEVILBISS EA, Gardner RM, NewsChaffer CJ, et al.Maternal FOLATE Status as a RISK FACTOR for Autism Spectrum Disorders: A Review of Existing Evidence.Br j nutr 2015; 114: 663-72.

[7] Kim Yi .Will Mandatic Folic Acid Fortification Prevent or Promote Cancer? AM J CLIN NUTR 2004; 80: 1123-8.

[8] Kim Yi.FOLATE and CANCER: a Tale of Dr.Jekyll and Mr.Hyde? AM J CLIN NUTR 2018; 107: 139-42.

[9] huo y, li j, qin x, et al.Effical of Folic Acid Therapy in Primary Prevention of Stroke AMONG Adults with Hypertension in China Jama 2015; 313: 1325-35.

[10] Williams J, Mai CT, Mulinare J, et al.Updated Estimates of Neural Tube DEFECTS Prevented by Mandator Folid Acid Fortification-United States, 1995-2011.MMWR Morb Mortal WKly Rep 2015; 64: 1-5.

[11] Wilson RD, Genetics C, Motherisk.Pre-conftingal Vitamin/Folic Acid Supplementation 2007: The user of folic acid in Combination with A Multivitamin Supplement for the Prevention of Nevice Defector.and Other Congenital Anomalies.J obstet gynaecol can 2007; 29: 1003-13.

[12] Shaw GM, O’Malley CD, WASSERMAN CR, et al.Maternal PericOnceptional Use of Multivitamins and Reduced Risk for Conotruncal Heart Defects and Limb DEFICIENCIES AMONG Office.AM J Med Genet 1995; 59: 536-45.

[13] Scholl to, Johnson WG.Folic Acid: Influence on the OUTCOME of Pregnancy.AM J CLIN NUTR 2000; 71: 1295S-303s.

[14] Morris MS, Fava M, Jacques PF, et al.Depression and FOLATE Status in the us Population.Psychother psychosom 2003; 72: 80-7.

[15] huang x, fan y, han x, et al.Association BetWeen Serum Vitamin Levels and depression in U.S.Adults 20 Years or Older Based On National Health and Nutropion Survey 2005-2006.Int j ENVIRON Res Public Health 2018; 15.

[16] Dietary Guidelines for Americans

[17] General Information about NTDS, Folic Acid, and FOLATE, CDC

[18] Folic acid, Webmd

[19] Folic acid, nhs.uk

[20] Vitamin B12, Harward.edu

[twenty one] DRUG Interactions Between Folic Acid and Vitamin B12, drag.com

[twenty two] Natural medicines.2018