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Hyaluronic acid oral and external use can beauty: analyze from the perspective of [Science]

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Hyaluronic acid, English is HyaluronicAcid In the beauty industry, it is a well-known component, and its strong moisturizing has become the tone ingredients of many skin care products.In the pharmaceutical industry, hyaluronic acid also has a lot of uses, such as providing sufficient lubrication ingredients for humans to start aging and dry joints to improve flexibility and reduce pain.

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What is hyaluronic acid?

Hyaluronic acid, also known as hyaluronic acid, English name: Hyaluronic Acid It is a transparent viscous substance.[1]Essence

Its main role is to maintain water and achieve the effect of lubrication.Hyaluronic acid produced by the human body will decrease with age, so many people will use it as a dietary supplement to obtain the effect of the body by external use and internal use.

Do you eat hyaluronic acid or apply it on your skin?

Hyaluronic acid can be eaten or used.

  • When eating, hyaluronic acid is a dietary supplement.When the human body eats, hyaluronic acid will increase the lubrication of people’s joints, improve joint flexibility, reduce pain, and enhance the skin’s water lock function to achieve the effects of recovery flexibility and fade fine lines.
  • During topical use, hyaluronic acid is added in various types of moisturizing skin creams and skin care essences.By contact with the skin, hyaluronic acid molecules penetrate the deep skin from the pores and lock the skin water to achieve the effect of moisturizing the skin.

Although hyaluronic acid itself can be used for external use or internal, when they serve as dietary supplements and external skin care products Can’t Change directly.

External hyaluronic acid
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Oral hyaluronic acid
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As a dietary supplement, the manufacturer will add some additional ingredients to the product to make it easier to take and be absorbed by the human body.Such components are not necessarily harmful to the skin.For example, some users will mix the powder in the hyaluronic acid capsule into liquidThe molecular weight of the hyaluronic acid with the specifications of the internal oriental specifications is formulated according to the absorption of the human body and intestines, so its absorption effect on the skin surface may not necessarily be better than inner.

For external use of skin care products, some other ingredients will be added, such as flavors, stabilizers, thickeners, other skin care essences, essential oils and other substances that can only be used for skin surfaces.Even the purest hyaluronic acid essence, the level of safety is limited to the topic level, concentration, texture, etc.cannot be eaten directly.

Therefore, when buying hyaluronic acid products, be sure to pay attention to the edible dietary supplements, or it is limited to external skin care products.

What are the effects of hyaluronic acid?

1.Improve the skin’s elasticity [external application/internal clothing]

About half of the hyaluronic acid in the human body exists in the surface skin, and they will keep water in the skin in combination with hydromics to keep the skin moisturizing and avoid dryness, wrinkles and other phenomena[2]Essence

However, various reasons in life will lead to the lack of hyaluronic acid in the skin, such as age growth, such as ultraviolet rays, environmental pollution, etc.[3]EssenceAt this time, it is necessary to supplement hyaluronic acid from the outside world to provide sufficient skin to the skin.You can take it internal or external.

Several experiments have proved that oral hyaluronic acid can effectively improve the skin state.For example, taking 120 to 240 mg of hyaluronic acid every day, after one month of continuous, can significantly improve the dryness of the skin[4], And can fade the wrinkles[5]Essence

As a skin care product, hyaluronic acid has a good reputation.A 2014 research report shows that female participants apply hyaluronic acid to local skin.After 8 weeks, different types of skin’s hydrophobic effects increased by 96%[6]Essence

At the same time, hyaluronic acid has different types of molecular binding types.Researchers have found that small molecular hyaluronic acid often shows better permeability than large molecular hyaluronic acid to help the skin start moisturizing from deeper[7]Essence

When hyaluronic acid acts directly on the skin, it also shows a certain antibacterial effect, which can relieve the redness and allergies caused by some skin inflammation.In some control experiments, hyaluronic acid care is provided for dermatitis and allergies.It can be seen significantly in time, and the control group using aurine-containing cream has no such effect.[8]Essence

2.Accelerate wound healing, prevent infection from [external use/internal service]

Hyaluronic acid is the main component of extraordinarily skin cell matrix.It participates in the regeneration process of the tissue.By regulating the inflammatory level of wounds and sending signals to the body to establish more blood vessels in the damaged area to help wound heal faster.According to the control experiments, compared with the control group that only uses placements without using any special treatment, the control group of hyaluronic acid is faster, and it can reduce more pain[9] [10]Essence

Hyaluronic acid also has antibacterial characteristics, which can achieve antibacterial effect by inhibiting bacterial growth.Therefore, when it is directly applied to an open wound, it can effectively reduce the risk of wound infection[11]EssenceThe antibacteriality of hyaluronic acid is mainly due to it that it can prevent the pathogenic preliminaries from adating to the wound tissue, or to prevent the formation of the pathogen from forming a biological film to cause inflammation.[12] Essence

The characteristic of hyaluronic acid combines its edible incompetence, which is also used in wound care after dental surgery, and wound care for some oral ulcers[13]Essence

At the same time, the hyaluronic acid supplement is supplemented during wound healing to ensure sufficient hyaluronic acid content in the body.It can provide sufficient hyaluronic acid levels to the skin to accelerate the self-healing of the skin near the wound.

3.Increase joint lubrication and reduce joint pain [Orals]

Hyaluronic acid also exists in the joints in large quantities, so that the bones are well lubricated, so as to avoid friction between the bones and the pain and degenerate diseases[14]Essence

Experimental data show that taking 80-200 mg of hyaluronic acid every day, after two months of continuous use, it proves that it can significantly reduce knee pain in patients with osteoarthritis, especially people between 40 and 70 years old.[15] [16]Essence

4.Relieve gastric acid reflux symptoms [Oral]

Gastric acid reflux is a situation that many people will happen.14-20% of all adults in the United States have some form of gastric acid reflux[17]Essence

Some gastric acid reflux is completely normal and harmless, and usually does not cause any symptoms, but some gastric acid reflux or often occurs.Symptoms such as sour taste and difficulty swallowing the oral cavity.

Hyaluronic acid is verified to help relieve damaged inner walls and accelerate its recovery process.A test tube study found that the mixture of hyaluronic acid and chondanic acid sulfate acts on the tissue of the throat damage to the gastric acid, which helps to accelerate the wound healing[18]Essence

A clinical control study also found that at the same time, taking hyaluronic acid and chondrose supplement and acid-deficient drugs at the same time can reduce the symptoms of discomfort by 60% compared to individual reducing drugs.[19]Essence

5.Relieve eye discomfort such as dry eye [external use]

However, when the secretion of tears of the human body or the evaporation of the tears will cause dry eye disease.Hyaluronic acid, which has excellent effects in moisturizing, is verified that it can be used to treat and relieve dry eye.Clinical data proves that dripping eye drops containing 0.2-0.4% hyaluronic acid can reduce dry eye symptoms and improve eye health[20]Essence

At the same time, contact lenses containing slow-release hyaluronic acid are also under development as possible treatment methods for dry eye disease[twenty one]EssenceIn addition, hyaluronic acid droplets are often used in ophthalmology surgery to reduce inflammation and accelerate wound healing[twenty two]Essence

Can hyaluronic acid really eliminate wrinkles and delay aging?

The reason why hyaluronic acid can eliminate wrinkles is because there are a large amount of hyaluronic acid in the skin.They will lock the water in the skin, keep the cells fill the state, support the skin, thereby preventing the creation of wrinkles, or fading the wrinkles that have appeared.Essence

  • For external use of skin care products, the hyaluronic acid of small molecules has proven to be better absorbed by the skin, penetrated into the skin deep, and brings deep moisturizing ability to the skin[7]Essence
  • As a supplementary supplement, it has also been proven to see the more obvious state improvement of the skin after a long time, relieve drying, dilute fine lines, etc.[4] [5]Essence

Can hyaluronic acid be used for a long time?

Because the skin contains hyaluronic acid naturally, it is safe for the skin to be used in hyaluronic acid, and the skin is always in an environment where the loss of moisture.Therefore, the skin supplement the skin in time, which can not only prevent the skin from being dry and rough, but also maintain the skin’s skin’s skin’s skin.Healthy state, prevent allergies and cracks.For aesthetics, sufficient water content can delay the generation of wrinkles, which is safe when using skin care products containing hyaluronic acid for a long time.

For orally, because the human body also produces hyaluronic acid, it is safe to take hyaluronic acid.At the same time, with the age of age, hyaluronic acid in the connective tissue of the human body will slowly lose, and timely supplementing sufficient hyaluronic acid can delay the signs of joint aging, such as pain and decreased flexibility.In addition to the beneficial joints of the joints, the intake of hyaluronic acid will also play a good moisturizing effect in the skin, bringing the skin to moisturize the skin, slowing the creation of wrinkles.Therefore, taking hyaluronic acid for a long time is also safe for most people.

How to use hyaluronic acid?

There are many forms of hyaluronic acid that acts on the skin, such as lotion, cream, essence, ointment, etc.Because other ingredients are usually added, it is best to apply according to the manufacturer’s use guide, but as far as the hyaluronic acid itself, every day, every dayIt is an ideal and safe way to apply it once in the morning and evening[twenty three]Essence

If the oral hyaluronic acid, if it is a diet supplement purchased by itself, take it according to the edible guidance of the supplement.If it is a prescription prescribed by the doctor, consume it according to the doctor’s order.

When orally, can hyaluronic acid and other vitamins be taken together?

Hyaluronic acid is safe for the human body.At present, there is no serious case report that occurs with other vitamins, so it is safe to take hyaluronic acid with other vitamins.

However, it is still recommended to consult a doctor before deciding to mix and consume, and decide whether it can be taken together on its own situation.

When orally, can hyaluronic acid, calcium, magnesium and other elements be taken together?

Hyaluronic acid currently does not have obvious reporting data in the human body in the human body, and because the human body itself produces hyaluronic acid, it is safe to think that hyaluronic acid and calcium and magnesium are safe.

However, it is still the best choice to consult a doctor before deciding to take it as a dietary supplement.

What are the side effects of hyaluronic acid?

When it is used in the skin, if it is used properly, hyaluronic acid is safe.In a few cases, it may cause allergic reactions.

When oral hyaluronic acid, if the amount of consumption is proper, hyaluronic acid is considered safe, and in a few cases, it may cause allergic reactions.

A research report on 60 patients with osteoarthritis shows that there is no negative effect under the measurement of 200 mg every day and a year of continued year.[twenty four]Essence

However, there are some evidence that cancer cells are very sensitive to hyaluronic acid, and taking supplements may make them grow faster, so it is recommended that people with cancer or cancer history avoid supplementing it[25]Essence

On the other hand, the impact of hyaluronic acid on the human body during pregnancy or breastfeeding has not been thoroughly studied, so these groups should be cautious.

Recommended hyaluronic acid essence [external use]

1.L ’Oreal Paris 1.5%pure hyaluronic acid essence

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L’Oreal Paris 1.5%pure hyaluronic acid essence contains strong moisturizing ingredient hyaluronic acid, and also contains vitamin C, which can immediately moisturize the skin, make the skin glorious, significantly abundant; reduce wrinkles and improve skin luster; it is effective for all skin tone.It is effective for all skin color.EssenceIt is suitable for facial and neck; does not contain spices, preservatives, mineral oils, and synthetic dyes; tested by dermatologists, suitable for all skin types, including dry skin, oily skin, mixed skin, sensitive skin and mature skin.

2.La Roche-POSAY Pure Hyaluronic acid Facial Essence

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La Roche-POSAY Pure Hyaluronic acid facial essence contains pure hyaluronic acid vitamin B5.The two components can help repair and re-enrich skin within 4 hours.Apply 3-4 drops every morning and evening on the face and neck, which can be used alone or as a supplement to the moisturizing cream.It also contains La Roche-Posay hot spring water.After being tested by dermatologists, it is safe and effective for sensitive skin.

3.Senallis cosmetics hyaluronic acid essence

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Senallis cosmetics hyaluronic acid essence can absorb water with a weight of 500 times itself.After applying it to the skin, it can bring a surprising moisturizing effect to the skin.The product contains a large bottle of 16 ounces, and a 2 ounce small dropper bottle.When the dropper bottle is used up, you can easily take out the tither bottle from the large bottle.Do not contain flavors, phthalate, and pheasters.

Instaskincare Facial hyaluronic acid serum

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Instaskincare facial hyaluronic acid essence is 100% pure medical clinical strength formula, and the ingredients are pure water, hyaluronic acid, and benzinanol (0.1%).Use twice a day for several weeks, you can clearly see the youthful changes in the skin.Moisturizing will not bring greasy feeling while moisturizing, suitable for all skin types.

Cerave hyaluronic acid facial essence

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Cerave Hyaluronic acid facial essence is prepared by the highest concentration of hyaluronic acid to help the skin look more moist and smooth.Contains vitamin B5, helping to soothe skin.The Cerave patent MVE component delivery technology continues to release moisturizing ingredients and provides 24 -hour long-lasting moisturizing.No preservatives and spices.Developed by dermatologists, the product is suitable for dry skin, sensitive skin, oily skin, easy to grow acne skin.

Neutrogena Hydro Boost Hyaluronic acid Essence

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Neutrogena Hydro Boost hyaluronic acid essence is prepared by 17% Hydration Complex.As part of the family skin care program, it can deeply moisturize and dry skin and make the skin particularly smooth and soft.Contains hyaluronic acid with high and low molecular weight, which can immediately replenish the skin.Hyaluronic acid with high molecular weight can be used as a moisturizing agent on the surface of the skin, and the hyaluronic acid of low molecular weight is designed to provide water deeply.Suitable for all skin and sensitive skin.

Recommended hyaluronic acid supplement [Oral]

1.Now Foods Supplements Hyaluronic acid Capsules

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Now Foods Supplements Hyaluronic acid Capsule contains 100 mg of hyaluronic acid per granular.Take 1 or 2 times a day.Each capsule can effectively play an effect of joint lubricant.At the same time, it contains L-proline, alpha sulfuric acid, and grape seed extract to create more complete formulas.In the production of equipment that meets GMP standards, it does not contain soybeans, sugar, nut ingredients, gluten, dairy products, eggs, etc., which are non-genetic foods, vegan, and Jewish cleaning.

2.Pure EncapSulations Hyaluronic acid Capsules

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Pure EncapSulations hyaluronic acid capsules can help skin hydration to maintain a healthy and young appearance, and reduce the appearance of fine lines and wrinkles, while supporting joint health, sufficient flexibility and comfort.It is made of high-quality ingredients from trusted suppliers, and is directed by nutritional experts to carefully manufacture and test to verify its effectiveness and purity.It does not contain wheat, eggs, nuts and peanuts, gluten, artificial pigments, spices and sweeteners, coatings and worm gums, genetically modified creatures, and unnecessary adhesives, fillers and preservatives.

3.Naturebell hyaluronic acid supplement agent

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Naturebell hyaluronic acid supplements, each 250 mg of hyaluronic acid and 25 mg of vitamin C, supports skin, hair and nail health, which is suitable for all men, women and children’s hyaluronic acid joint supplements.The third party has been tested by purity and quality, and does not contain genetically modified organisms, gluten, dairy products, sugar, soybeans and nuts.

4.Toniiq hyaluronic acid capsule

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Toniiq hyaluronic acid capsules contain 250 mg of the highest quality hyaluronic acid powder each.All raw materials are fermented production processes to ensure that 95% of the standardization purity is used in accordance with moral ways.In the device manufacturing that meets GMP certification and NSF approval, all products have been tested by third-party independent laboratories to ensure purity and quality.

references

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[2] Eleni Papakonstantinou, Michael Roth, and George Karakiulakis.Hyaluronic Acid: A Key Molecule in Skin Aging Dermatondocrinol.2012 Jul.

[3] Russell M L Simpson, SOMA MERAN, David Thomas, Philip Stephens, Timothy Bowen, Robert Steadman, ALED Phillips.Age-Related Changes in Pericelular Hyaluronan Organization Leads to Impaired Dermal Fibroblast to Myofibroblast Differentiation.AM J Pathol.2009 Nov.

[4] CHINATSU KAWADA, TAKUSHI YOSHIDA, Hideto Yoshida, Ryosuke Matsuoka 1, Wakako Sakamoto, WATARU ODANAKA, TOST Ki Kanemitsu, YASUNOBU MASUDA, OSAMU Urushibata.INGETED HYALURONAN MOISTURIZES DRY SKIN.Nutr j.2014 jul.

[5] Mariko OE, Seigo Sakai, Hideto Yoshida, NaO Okado, Haruna Kaneda, YASUNOBU MASUDA, OSAMU Urushibata.Oral Hyaluronan Relieves Wrinkles: A Double-Blinded, Placebo-Controlled Study Over A 12-Week Period CLIN COSMET Investig Dermatol.2017 Jul.

[6] S.Manjula Jegasothy, MD, A Valentina Zabolotniaia, MD, B and Stephan Bieldeldt, Dipl.BIO.-GC.Effical of a New Topicano-Hyaluronic Acid in Humans. J clin aesthet dermatol.2014 mar.

[7] Tatjana Pavicic, Gerd G GAUGLITZ, Peter Lersch, Khadija Schwach-ABDELLAUUI, Birgitte Malle, Hans Christian Korting, Mike Farwick.Effical of Cream-Based Novel Formulations of Hyaluronic Acid of Different Molecular Weights in Anti-Wrinkle Treatment J drugs dermatol.2011 sep.

[8] Zoe Diana Draelos.A Clinical Evaluation of the Comparable Effical of Hyaluronic Acid-Based Foam and Ceramide-Containing Cream in The Treatment of Mild-Moderal Atopic Der matitis. J cosmet dermatol.2011 sep.

[9] o dereure, m czubek, P Combemale.Effical and Safety of Hyaluronic Acid in Treatment of Leg Ulcers: A Double-Blind Rct J wound care.2012 mar.

[10] Philippe Humbers, Jacek Mikosinki, Hakima Benchikhi, Fraançois-André Allart.Effical and Safety of a Gauze Pad Containing Hyaluronic Acid in Treatment of Leg Ulcers OF VENOUS Origin: A Double-Blind, Controlled Trial. Int Wound J.2013 Apr.

[11] P PIRNAZAR, L Wolinsky, S Nachnani, S Haake, A Pilloni, G W Bernard.Bacteriostatic Effects of Hyaluronic Acid. J Periodontol.1999 APR.

[12] C.L.ROMANò, E.De Vecchi, M.Bortolin, I.Moreli, and L.Drago.Hyaluronic Acid and Its Composits AS A Local Antimicrobial/Antiadhesive Barrier. J bone jt infect.Jan, 2017.

[13] Manuele Casale, Antonio Moffa, Paola Vella, Lorenzo Sabatino, Francesco Capuano, Beatrice Salvinelli, Michele Antonio Lopez, FranceSco Carinci, Fabrizio Salv Inelli.Hyaluronic Acid: Perspectives in Dentistry.A Systematic Review. Int J Immunopathol Pharmacol.

[14] Grigorij Kogan, Ladislav Soltés, Robert Stern, Peter Gemer.Hyaluronic Acid: a Natural Biopolymer with a BroadE of Biometal and Industrial Applications. Biotechnol lett.2007 Jan.

[15] Douglas S Kalman, Maria Heimer, Anita Valdeon, Howard Schwartz, Eric Sheldon.Effect of a natural extract of Chicken Combs with a high content of hyaluronic Acid (Hyal-Joint) On Pain RELIEF and Quality of Life in Subjects With Knee Oteoar Thritis: A Pilot Randomized Double-Blind Placebo-Controlled Trial. Nutr j.2008 Jan.

[16] Toshiyuki Tashiro, Satoshi Seino, Toshihide Sato, Ryosuke Matsuoka, YASUNOBU MASUDA, Naoshi Fukui.ORAL Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoartis: A Double-Blind, Placebo-Controlled Study Over Period. ScientificWorldJournal.2012.

[17] J DENT, H B El-Serag, M-A Wallander, S Johansson.EPIDEMIOGY of Gastro-OESOPHAGEAL Reflux Disease: A Systematic Review. Gut.2005 May.

[18] Massimo P Di Simone, Fabio Baldi, Valentina Vasina, Fabrizio Scorrano, Maria Laura Bacci, AntoneLa Ferrieri, and Gilberto Poggioli.Barrier Effect of Esoxx® on ESOPHAGEAL MUCOSAL DAMAGE: Experimental Study on Ex-Vivo Swine Model. Clin exp Gastroenterol.2012.

[19] V.Savarino, F.Pace, C.Scarpignato, Corresponding Author, The Esoxx Study Group.RANDOMISED Clinical TRIAL: Mucosal Protection Combined with Acid SUPPression in the Treatment of Non‐erosive Reflux Disease -Effical of Esoxx, A Hyaluronic AC id –Chondroitin Sulphate Based Bioadhesive Formulation.ALIME PHARMACOL THER.2017 Mar.

[20] M Irster, G J Orsoni, G Gamba, M Taffara, P Mangiafico, S Giuffrida, M Rolando.Improvement of the Ocular Surface USIPOTONIC 0.4% Hyaluronic Acid Drops in KeratoratoratoConctivitis Sicca. Eye (Lond).2000 DEC.

[21] Maryam ali, mark e bybrne.Controlled Release of High Molecular Weight Hyaluronic Acid from Molecularly IMPRINTED HYDROGEL CONTACT LENSES.Pharm res.2009 mar.

[22] j a p gomes, r amankwah, a Powell-richards, and h s dua.Sodium Hyaluronate (Hyaluronic Acid) Promotes Migration of Human Corneal Epithelial Cells in Vitro.Br j obHthalmol.2004 jun.

[23] S.Manjula Jegasothy, MD, A Valentina Zabolotniaia, MD, B and Stephan Bieldeldt, Dipl.Bio.-ingc.Effical of a New Topical Nano-Hyaluronic Acid in Humans. J clin aesthet dermatol.2014 mar.

[24] Anne W s Rutjes, Peter Jüni, Bruno R Da Costa, SVEN TRELLE, Eveline Nüesch, Stephan Reichenbach.Viscosupplementation for OSTEOARITIS of the Knee: A Systematic Review and Meta-Analysis. Ann intern med.2012 AUG.

[25] Naoki itano, lisheng zhuo, koji kimata.IMPACT of the Hyaluronan-Rich Tumor Microenvalonment on Cancer Initiation and Progression.Cancer sci.2008 SEP.